Two goals from former player Milan Baros, along with a stunning strike from Johan Elmander, saw Liverpool sink to their second friendly defeat in a row against Galatasaray.
Kenny Dalglish named a side compiled of fringe players, with the likes of Emiliano Insua, Philipp Degen and Christian Poulsen all starting for the Reds.
A handful of youngsters were also on the Liverpool team sheet, with John Flanagan, Martin Kelly, Jack Robinson and Jonjo Shelvey getting a run out in Istanbul.
Galatasaray, on the other hand, named a strong squad, with former Liverpool striker Milan Baros starting up front alongside ex Bolton forward Johan Elmander. Highly rated Turkish winger Arda Turan also started for the hosts with new signing Fellipe Melo, formerly of Juventus.
The first-half was scrappy throughout, with two bookings being made in the opening twenty five minutes, one for either side, with Liverpool midfielder Jonjo Shelvey and Galatasaray defender Hakan Balta both finding themselves being shown yellow by the referee.
Galatasaray came close to increasing their lead with just over half an hour played as Servet Cetin connected with a cross from the right and forced Doni to make a great save to deny the hosts another goal.
Minutes later and Liverpool had their best chance of the first-half, with Sotirios Kyrgiakos connecting with a long-ball into the box and heading it down to Martin Kelly, who fired his shot wide despite being clear through on goal with only the keeper to beat.
With half-time fast approaching, Milan Baros doubled his own and Galatasaray's goal tally, heading the ball in past Doni at the far post following a corner.
Liverpool started the second-half much better than they had finished the first, pressing high up the pitch and passing the ball at pace, denying the hosts the possession they had in the opening period.
Dalglish had opted to bring on seasoned players such as Dirk Kuyt and Alberto Aquilani to try and help with the attacking play after Carroll had been isolated up front for much of the first period. Brad Jones was also brought on in place of Doni.
With just over an hour played Liverpool's improved performance nearly paid dividends, with Joe Cole spraying the ball out wide to Kuyt, who cut inside and played it to Aquilani, with the Italian firing a low shot towards the right-hand corner which forced Ceylan to make a great save.
Jay Spearing, who impressed in the latter stages of the last campaign, was brought on with 70 minutes to go, replacing Jonjo Shelvey in the middle of the park.
With just ten minutes to go Andy Carroll had another chance to get Liverpool a goal back, latching onto a cross from Kuyt, but his header was easily collected Ceylan at the near post, with Conor Coady and Andre Wisdom both coming on shortly after.
Galatasaray extended their lead shortly before the end of the game, with Johan Elmander, the former Bolton man, catching the ball perfectly on the volley from just outside the box, giving Brad Jones no chance of saving the shot as the Reds back four failed to close down the front man.
Kenny Dalglish will be unlikely to worry too much following the result. The Liverpool team was comprised of fringe players and youngsters, with Andy Carroll being the only player being almost guaranteed a position on the Reds team sheet come the start of the season.
Galatasaray, who were expecting to start their season next weekend, were also clearly further along in their pre-season training, being more than capable of out running their visiting opposition.